In 2005, amid mass protests against the pharmaceutical company WilPharma, Claire Redfield, an activist with the human rights organization TerraSave, arrives at the Harvardville airport. Suddenly a plane carrying people infected with the T-virus crashes near the airport. As a result of the disaster, the airport building fills with hordes of zombies, and the situation becomes critical. The military arrives at the scene, and among them is Leon S. Kennedy. Together with a special forces unit, he launches an operation to rescue the survivors.
During the rescue operation, Leon and his team find Claire and a group of survivors, among them Senator Ron Davis, known for his support of WilPharma. Together they try to make their way out of the airport, overcoming numerous obstacles and fighting off zombies. In this tense situation it becomes clear that something more than a mere accident may be behind the disaster, and the heroes must not only save themselves but also uncover the truth about WilPharma.
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